Visible-Light-Mediated Generation of Nitrile Oxides for the Photoredox Synthesis of Isoxazolines and Isoxazoles

Thomas Svejstrup; Wojciech Zawodny; James J.  Douglas; Damon  Bidgelli; Nadeem S Sheikh; Daniele Leonori

doi:10.1039/C6CC06029C

Visible-Light-Mediated Generation of Nitrile Oxides for the Photoredox Synthesis of Isoxazolines and Isoxazoles

Thomas Svejstrup, Wojciech Zawodny, James J. Douglas, Damon Bidgelli, Nadeem S Sheikh, Daniele Leonori

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Abstract

Visible-light photoredox catalysis enables the synthesis of
biologically relevant isoxazolines and isoxazoles from
hydroxyimino acids. The process shows broad functional group
compatibility and mechanisitic and computational studies support
a visible-light-mediated generation of nitrile oxides by two
sequential oxidative single electron transfer processes.

Original language	English
Journal	Chemical Communications- Royal Society of Chemistry
Early online date	21 Sept 2016
DOIs	https://doi.org/10.1039/C6CC06029C
Publication status	Published - 2016

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title = "Visible-Light-Mediated Generation of Nitrile Oxides for the Photoredox Synthesis of Isoxazolines and Isoxazoles",

abstract = "Visible-light photoredox catalysis enables the synthesis ofbiologically relevant isoxazolines and isoxazoles fromhydroxyimino acids. The process shows broad functional groupcompatibility and mechanisitic and computational studies supporta visible-light-mediated generation of nitrile oxides by twosequential oxidative single electron transfer processes.",

author = "Thomas Svejstrup and Wojciech Zawodny and Douglas, {James J.} and Damon Bidgelli and Sheikh, {Nadeem S} and Daniele Leonori",

year = "2016",

doi = "10.1039/C6CC06029C",

language = "English",

journal = "Chemical Communications- Royal Society of Chemistry",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

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T1 - Visible-Light-Mediated Generation of Nitrile Oxides for the Photoredox Synthesis of Isoxazolines and Isoxazoles

AU - Svejstrup, Thomas

AU - Zawodny, Wojciech

AU - Douglas, James J.

AU - Bidgelli, Damon

AU - Sheikh, Nadeem S

AU - Leonori, Daniele

PY - 2016

Y1 - 2016

N2 - Visible-light photoredox catalysis enables the synthesis ofbiologically relevant isoxazolines and isoxazoles fromhydroxyimino acids. The process shows broad functional groupcompatibility and mechanisitic and computational studies supporta visible-light-mediated generation of nitrile oxides by twosequential oxidative single electron transfer processes.

AB - Visible-light photoredox catalysis enables the synthesis ofbiologically relevant isoxazolines and isoxazoles fromhydroxyimino acids. The process shows broad functional groupcompatibility and mechanisitic and computational studies supporta visible-light-mediated generation of nitrile oxides by twosequential oxidative single electron transfer processes.

U2 - 10.1039/C6CC06029C

DO - 10.1039/C6CC06029C

M3 - Article

SN - 1359-7345

JO - Chemical Communications- Royal Society of Chemistry

JF - Chemical Communications- Royal Society of Chemistry

ER -

Visible-Light-Mediated Generation of Nitrile Oxides for the Photoredox Synthesis of Isoxazolines and Isoxazoles

Abstract

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