VISTA-Rehab: A resource for stroke rehabilitation trials

Myzoon Ali, Ann Ashburn, Audrey Bowen, Eric Brodie, Susan Corr, Avril Drummond, Judi Edmans, John Gladman, Lalit Kalra, Peter Langhorne, Kennedy R. Lees, Nadina Lincoln, Pip Logan, Gillian Mead, Emma Patchick, Alex Pollock, Val Pomeroy, Catherine Sackley, Katherina S. Sunnerhagen, Paulette Van VlietMarion Walker, Marian Brady

    Research output: Contribution to journalArticlepeer-review


    Background Stroke rehabilitation is a complex intervention. Many factors influence the interaction between the patient and the elements of the intervention. Rehabilitation interventions are aimed at altering different domains of patient outcome including body functions, activity and participation. As a consequence, randomised clinical trials in this area are difficult to design. We developed an archive of stroke rehabilitation trials (VISTA-Rehab) to act as a resource to help trialists model and design future rehabilitation studies.Methods We developed specific eligibility criteria for the entry of stroke rehabilitation trials into the archive. We established a Steering Committee to oversee projects and publications and commenced the recruitment of rehabilitation trials into this resource.Results As of August 2009, VISTA-Rehab contains data from 23 stroke rehabilitation trials (>3400 patients). Demographic data, including age [median=73, interquartile range (63,79)], gender (male=53%) and initial dependency [median baseline Barthel index score=6, interquartile range (9,19)], are available for all patients. Outcome measures include the modified Rankin Scale, Barthel Index, Rivermead Motor Assessment, Fugl-Meyer Assessment, General Health Questionnaire and Nottingham Extended Activities of Daily Living Scale.Conclusion VISTA-Rehab expands the Virtual International Stroke Trials Archive to include rehabilitation trials. Anonymised data can be used to examine questions specific to stroke rehabilitation and to generate novel hypotheses. © 2010 The Authors. International Journal of Stroke © 2010 World Stroke Organization.
    Original languageEnglish
    Pages (from-to)447-452
    Number of pages5
    JournalInternational Journal of Stroke
    Issue number6
    Publication statusPublished - Dec 2010


    • Clinical trial
    • Database
    • Natural history
    • Stroke rehabilitation
    • Trial design


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