Vitamin B metabolism in Plasmodium falciparum as a source of drug targets

Ingrid B. Müller, John E. Hyde, Carsten Wrenger

    Research output: Contribution to journalArticlepeer-review


    The malaria parasite Plasmodium falciparum depends primarily on nutrient sources from its human host. Most compounds, such as glucose, purines, amino acids, as well as cofactors and vitamins, are abundantly available in the host cell, and can be readily salvaged by the parasite. However, in some cases the parasite can also synthesize cofactors de novo in reactions that appear to be essential. Importantly, the three biosynthetic pathways that produce vitamins B1, B6 and B9 are absent from the host, but are well established in P. falciparum. This review summarizes and updates the current knowledge of vitamin B de novo synthesis and salvage in P. falciparum and focuses on their potential as targets for drug intervention. © 2009 Elsevier Ltd.
    Original languageEnglish
    Pages (from-to)35-43
    Number of pages8
    JournalTrends in parasitology
    Issue number1
    Publication statusPublished - Jan 2010


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