Vitamin D and Age-Related Macular Degeneration

AG Layana, AM Minnella, G Garhofer, Tariq Aslam, FG Holz, C Delcourt, E Souied, JM Seddon

Research output: Contribution to journalArticlepeer-review


In recent years, the relationship between vitamin D and health has received growing attention from the scientific and medical communities. Vitamin D deficiencies have been repeatedly associated with various acute and chronic diseases, including age-related macular degeneration (AMD). Its active metabolite, 1α,25-dihydoxy vitamin D, acts as a modulator of cell proliferation, differentiation and apoptosis, and cumulative data from experimental and observational studies suggest that relatively a lower vitamin D status could be a potential risk factor for the development of early and/or late AMD. Herein, we made a narrative review of the mechanisms linking a potential role of vitamin D with the current concepts of AMD pathophysiology.
Original languageEnglish
Publication statusPublished - 13 Oct 2017


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