Vitamin D for the treatment of painful diabetic neuropathy

Abdul Basit; Khalid Abdul Basit; Asher Fawwad; Fariha Shaheen; Nimra Fatima; Ioannis Petropoulos; Uazman Alam; Rayaz Malik

doi:10.1136/bmjdrc-2015-000148

Vitamin D for the treatment of painful diabetic neuropathy

Abdul Basit, Khalid Abdul Basit, Asher Fawwad, Fariha Shaheen, Nimra Fatima, Ioannis Petropoulos, Uazman Alam, Rayaz Malik

Division of Diabetes, Endocrinology & Gastroenterology (L5)

Research output: Contribution to journal › Article › peer-review

Abstract

OBJECTIVE: To assess the effect of high-dose vitamin D in patients with painful diabetic neuropathy.

METHODS: A single intramuscular dose of 600 000 IU vitamin D was administered, and the effects on metabolic parameters and neuropathic pain assessed over 20 weeks.

RESULTS: 143 participants with predominantly type 2 diabetes, aged 52.31±11.48 years, with a Douleur Neuropathique 4 (DN4) score (3.0±1.8), total McGill pain score (21.2±14.9), and Short Form McGill Pain Questionnaire (SFMPQ) score (2.1±0.9), were enrolled. The baseline 25-hydroxyvitamin D (25(OH)D) level was 31.7±23.3 ng/mL and 58 (40.5%) patients showed evidence of vitamin D deficiency (25(OH)D<20 ng/mL). Intramuscular administration of vitamin D resulted in a significant increase in 25(OH)D (46.2±10.2 ng/mL, p<0.0001) and a reduction in positive symptoms on the DN4 (p<0.0001), total pain score (p<0.0001), and SFMPQ (p<0.0001).

CONCLUSIONS: Treatment with a single intramuscular dose of 600 000 IU of vitamin D in patients with painful diabetic neuropathy is associated with a significant decrease in the symptoms of painful diabetic neuropathy.

TRIAL REGISTRATION NUMBER: BIDE-12/2014.

Original language	English
Pages (from-to)	e000148
Journal	BMJ open diabetes research & care
Volume	4
Issue number	1
DOIs	https://doi.org/10.1136/bmjdrc-2015-000148
Publication status	Published - 10 Feb 2016

Keywords

Journal Article

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1136/bmjdrc-2015-000148Licence: CC BY

Cite this

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title = "Vitamin D for the treatment of painful diabetic neuropathy",

abstract = "OBJECTIVE: To assess the effect of high-dose vitamin D in patients with painful diabetic neuropathy.METHODS: A single intramuscular dose of 600 000 IU vitamin D was administered, and the effects on metabolic parameters and neuropathic pain assessed over 20 weeks.RESULTS: 143 participants with predominantly type 2 diabetes, aged 52.31±11.48 years, with a Douleur Neuropathique 4 (DN4) score (3.0±1.8), total McGill pain score (21.2±14.9), and Short Form McGill Pain Questionnaire (SFMPQ) score (2.1±0.9), were enrolled. The baseline 25-hydroxyvitamin D (25(OH)D) level was 31.7±23.3 ng/mL and 58 (40.5%) patients showed evidence of vitamin D deficiency (25(OH)D<20 ng/mL). Intramuscular administration of vitamin D resulted in a significant increase in 25(OH)D (46.2±10.2 ng/mL, p<0.0001) and a reduction in positive symptoms on the DN4 (p<0.0001), total pain score (p<0.0001), and SFMPQ (p<0.0001).CONCLUSIONS: Treatment with a single intramuscular dose of 600 000 IU of vitamin D in patients with painful diabetic neuropathy is associated with a significant decrease in the symptoms of painful diabetic neuropathy.TRIAL REGISTRATION NUMBER: BIDE-12/2014.",

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T1 - Vitamin D for the treatment of painful diabetic neuropathy

AU - Basit, Abdul

AU - Basit, Khalid Abdul

AU - Fawwad, Asher

AU - Shaheen, Fariha

AU - Fatima, Nimra

AU - Petropoulos, Ioannis

AU - Alam, Uazman

AU - Malik, Rayaz

PY - 2016/2/10

Y1 - 2016/2/10

N2 - OBJECTIVE: To assess the effect of high-dose vitamin D in patients with painful diabetic neuropathy.METHODS: A single intramuscular dose of 600 000 IU vitamin D was administered, and the effects on metabolic parameters and neuropathic pain assessed over 20 weeks.RESULTS: 143 participants with predominantly type 2 diabetes, aged 52.31±11.48 years, with a Douleur Neuropathique 4 (DN4) score (3.0±1.8), total McGill pain score (21.2±14.9), and Short Form McGill Pain Questionnaire (SFMPQ) score (2.1±0.9), were enrolled. The baseline 25-hydroxyvitamin D (25(OH)D) level was 31.7±23.3 ng/mL and 58 (40.5%) patients showed evidence of vitamin D deficiency (25(OH)D<20 ng/mL). Intramuscular administration of vitamin D resulted in a significant increase in 25(OH)D (46.2±10.2 ng/mL, p<0.0001) and a reduction in positive symptoms on the DN4 (p<0.0001), total pain score (p<0.0001), and SFMPQ (p<0.0001).CONCLUSIONS: Treatment with a single intramuscular dose of 600 000 IU of vitamin D in patients with painful diabetic neuropathy is associated with a significant decrease in the symptoms of painful diabetic neuropathy.TRIAL REGISTRATION NUMBER: BIDE-12/2014.

AB - OBJECTIVE: To assess the effect of high-dose vitamin D in patients with painful diabetic neuropathy.METHODS: A single intramuscular dose of 600 000 IU vitamin D was administered, and the effects on metabolic parameters and neuropathic pain assessed over 20 weeks.RESULTS: 143 participants with predominantly type 2 diabetes, aged 52.31±11.48 years, with a Douleur Neuropathique 4 (DN4) score (3.0±1.8), total McGill pain score (21.2±14.9), and Short Form McGill Pain Questionnaire (SFMPQ) score (2.1±0.9), were enrolled. The baseline 25-hydroxyvitamin D (25(OH)D) level was 31.7±23.3 ng/mL and 58 (40.5%) patients showed evidence of vitamin D deficiency (25(OH)D<20 ng/mL). Intramuscular administration of vitamin D resulted in a significant increase in 25(OH)D (46.2±10.2 ng/mL, p<0.0001) and a reduction in positive symptoms on the DN4 (p<0.0001), total pain score (p<0.0001), and SFMPQ (p<0.0001).CONCLUSIONS: Treatment with a single intramuscular dose of 600 000 IU of vitamin D in patients with painful diabetic neuropathy is associated with a significant decrease in the symptoms of painful diabetic neuropathy.TRIAL REGISTRATION NUMBER: BIDE-12/2014.

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Vitamin D for the treatment of painful diabetic neuropathy

Abstract

Keywords

UN SDGs

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