Abstract
Background - Vitamin E (α-tocopherol) is an important endogenous antioxidant and may also act as an anticarcinogen. Aim - To determine the vitamin E status of subjects with, and without, gastroduodenal inflammation and Helicobacter pylori infection. Subjects - 36 patients undergoing routine gastroscopy for investigation of dyspepsia. Methods - High performance liquid chromatography with fluorometric detection was used to determine α- tocopherol values. Results - In H pylori negative subjects with normal gastroduodenal histology (n=11) median α-tocopherol values (ng/mg tissue weight) were significantly higher in the corpus (16.4, interquartile range (IQR) 8.9-22.6) than in the antrum (3.0, IQR 2.6-6.7, p=0.001) or duodenum (6.7, IQR 2.5-8.4, p=0.001). H pylori infection (n = 19) was associated with a reduction in the corpus α-tocopherol values (median 8.3, IQR 4.9-13.7, p
| Original language | English |
|---|---|
| Pages (from-to) | 31-35 |
| Number of pages | 4 |
| Journal | Gut |
| Volume | 39 |
| Issue number | 1 |
| Publication status | Published - 1996 |
Keywords
- antioxidants
- gastroduodenal inflammation
- Helicobacter pylori
- vitamin E