Volumetric and area-based breast density measurement in the predicting risk of cancer at screening (PROCAS) study

Jamie C. Sergeant, Jane Warwick, Gareth Evans, Anthony Howell, Michael Berks, Paula Stavrinos, Sarah Sahin, Mary Wilson, Alan Hufton, Iain Buchan, Susan M. Astley

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review


Mammographic density, defined as the proportion of the breast area in a mammogram that contains fibroglandular tissue, is associated with risk of breast cancer. However, measures of mammographic density are subject to variation in the underlying imaging process and in the assessments of observers. Automatic volumetric measures of breast density remove much of this variability, but their association with risk is less well established. We present density measurements produced using area-based visual analogue scales (VAS) and by volumetric assessment software (Quantra TM, Hologic Inc.) in the PROCAS study. The distributions of VAS scores (n = 22 327) and volumetric quantities (n = 11 653) are given, as are their relationships for subjects with results by both (n = 11 096), but these are not directly comparable as one is area-based and the other volumetric. Inter-observer variability in visual area-based estimation is examined by a scatter plot matrix. © 2012 Springer-Verlag Berlin Heidelberg.
Original languageEnglish
Title of host publicationLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)|Lect. Notes Comput. Sci.
PublisherSpringer Nature
Number of pages7
ISBN (Print)9783642312700
Publication statusPublished - 2012
Event11th International Workshop on Breast Imaging, IWDM 2012 - Philadelphia, PA
Duration: 1 Jul 2012 → …


Conference11th International Workshop on Breast Imaging, IWDM 2012
CityPhiladelphia, PA
Period1/07/12 → …


  • area-based measures
  • Breast density
  • interobserver variation
  • Quantra
  • volumetric measures


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