Volumetric and area-based measures of mammographic density in women with and without cancer

Leila Nutine; Jamie C. Sergeant; Julie Morris; Paula Stavrinos; D. Gareth Evans; Tony Howell; Caroline Boggis; Mary Wilson; Nicky Barr; Susan M. Astley

doi:10.1007/978-3-642-31271-7_76

Volumetric and area-based measures of mammographic density in women with and without cancer

Leila Nutine, Jamie C. Sergeant, Julie Morris, Paula Stavrinos, D. Gareth Evans, Tony Howell, Caroline Boggis, Mary Wilson, Nicky Barr, Susan M. Astley

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

We compare mammographic density in 44 women with screen-detected breast cancer and a control group of 923 women with normal screening mammograms. Multiple regression was used to compare the effects of case-control status on breast density of the contra-lateral breast. Two breast density measures were investigated: the average visual assessment, recorded on a visual analogue scale (VAS), for the two views and two independent readers; and volumetric percentage density measured by Quantra TM. We adjusted for confounding factors of BMI, HRT use, age and menopausal status. Initially there was no significant difference in mean percentage density between cases and controls using either measure of density: VAS (cases 27.5%, controls 26.9%) and Quantra TM (cases 1.2%, controls 18.2%). However, when confounding factors were controlled for, case-control status had a statistically significant effect on breast density as measured by Quantra TM (adjusted means: cases 19.2%, controls 14.8%; p = 0.002) but not by VAS. © 2012 Springer-Verlag Berlin Heidelberg.

Original language	English
Title of host publication	Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)\|Lect. Notes Comput. Sci.
Place of Publication	Berlin Heidelberg
Publisher	Springer Nature
Pages	589-595
Number of pages	6
Volume	7361
ISBN (Print)	9783642312700
DOIs	https://doi.org/10.1007/978-3-642-31271-7_76
Publication status	Published - 2012
Event	11th International Workshop on Breast Imaging, IWDM 2012 - Philadelphia, PA Duration: 1 Jul 2012 → …

Conference

Conference	11th International Workshop on Breast Imaging, IWDM 2012
City	Philadelphia, PA
Period	1/07/12 → …

Keywords

breast cancer
Breast density
mammography
Quantra
Visual Analogue Scale
volumetric

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/978-3-642-31271-7_76

Cite this

Nutine, L., Sergeant, J. C., Morris, J., Stavrinos, P., Gareth Evans, D., Howell, T., Boggis, C., Wilson, M., Barr, N., & Astley, S. M. (2012). Volumetric and area-based measures of mammographic density in women with and without cancer. In Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)|Lect. Notes Comput. Sci. (Vol. 7361, pp. 589-595). Springer Nature. https://doi.org/10.1007/978-3-642-31271-7_76

Nutine, Leila ; Sergeant, Jamie C. ; Morris, Julie et al. / Volumetric and area-based measures of mammographic density in women with and without cancer. Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)|Lect. Notes Comput. Sci.. Vol. 7361 Berlin Heidelberg : Springer Nature, 2012. pp. 589-595

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title = "Volumetric and area-based measures of mammographic density in women with and without cancer",

abstract = "We compare mammographic density in 44 women with screen-detected breast cancer and a control group of 923 women with normal screening mammograms. Multiple regression was used to compare the effects of case-control status on breast density of the contra-lateral breast. Two breast density measures were investigated: the average visual assessment, recorded on a visual analogue scale (VAS), for the two views and two independent readers; and volumetric percentage density measured by Quantra TM. We adjusted for confounding factors of BMI, HRT use, age and menopausal status. Initially there was no significant difference in mean percentage density between cases and controls using either measure of density: VAS (cases 27.5%, controls 26.9%) and Quantra TM (cases 1.2%, controls 18.2%). However, when confounding factors were controlled for, case-control status had a statistically significant effect on breast density as measured by Quantra TM (adjusted means: cases 19.2%, controls 14.8%; p = 0.002) but not by VAS. {\textcopyright} 2012 Springer-Verlag Berlin Heidelberg.",

keywords = "breast cancer, Breast density, mammography, Quantra, Visual Analogue Scale, volumetric",

author = "Leila Nutine and Sergeant, {Jamie C.} and Julie Morris and Paula Stavrinos and {Gareth Evans}, D. and Tony Howell and Caroline Boggis and Mary Wilson and Nicky Barr and Astley, {Susan M.}",

year = "2012",

doi = "10.1007/978-3-642-31271-7_76",

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Nutine, L, Sergeant, JC, Morris, J, Stavrinos, P, Gareth Evans, D, Howell, T, Boggis, C, Wilson, M, Barr, N & Astley, SM 2012, Volumetric and area-based measures of mammographic density in women with and without cancer. in Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)|Lect. Notes Comput. Sci.. vol. 7361, Springer Nature, Berlin Heidelberg, pp. 589-595, 11th International Workshop on Breast Imaging, IWDM 2012, Philadelphia, PA, 1/07/12. https://doi.org/10.1007/978-3-642-31271-7_76

Volumetric and area-based measures of mammographic density in women with and without cancer. / Nutine, Leila; Sergeant, Jamie C.; Morris, Julie et al.
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)|Lect. Notes Comput. Sci.. Vol. 7361 Berlin Heidelberg: Springer Nature, 2012. p. 589-595.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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AU - Howell, Tony

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N2 - We compare mammographic density in 44 women with screen-detected breast cancer and a control group of 923 women with normal screening mammograms. Multiple regression was used to compare the effects of case-control status on breast density of the contra-lateral breast. Two breast density measures were investigated: the average visual assessment, recorded on a visual analogue scale (VAS), for the two views and two independent readers; and volumetric percentage density measured by Quantra TM. We adjusted for confounding factors of BMI, HRT use, age and menopausal status. Initially there was no significant difference in mean percentage density between cases and controls using either measure of density: VAS (cases 27.5%, controls 26.9%) and Quantra TM (cases 1.2%, controls 18.2%). However, when confounding factors were controlled for, case-control status had a statistically significant effect on breast density as measured by Quantra TM (adjusted means: cases 19.2%, controls 14.8%; p = 0.002) but not by VAS. © 2012 Springer-Verlag Berlin Heidelberg.

AB - We compare mammographic density in 44 women with screen-detected breast cancer and a control group of 923 women with normal screening mammograms. Multiple regression was used to compare the effects of case-control status on breast density of the contra-lateral breast. Two breast density measures were investigated: the average visual assessment, recorded on a visual analogue scale (VAS), for the two views and two independent readers; and volumetric percentage density measured by Quantra TM. We adjusted for confounding factors of BMI, HRT use, age and menopausal status. Initially there was no significant difference in mean percentage density between cases and controls using either measure of density: VAS (cases 27.5%, controls 26.9%) and Quantra TM (cases 1.2%, controls 18.2%). However, when confounding factors were controlled for, case-control status had a statistically significant effect on breast density as measured by Quantra TM (adjusted means: cases 19.2%, controls 14.8%; p = 0.002) but not by VAS. © 2012 Springer-Verlag Berlin Heidelberg.

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KW - Breast density

KW - mammography

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BT - Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)|Lect. Notes Comput. Sci.

PB - Springer Nature

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Y2 - 1 July 2012

ER -

Nutine L, Sergeant JC, Morris J, Stavrinos P, Gareth Evans D, Howell T et al. Volumetric and area-based measures of mammographic density in women with and without cancer. In Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)|Lect. Notes Comput. Sci.. Vol. 7361. Berlin Heidelberg: Springer Nature. 2012. p. 589-595 doi: 10.1007/978-3-642-31271-7_76

Volumetric and area-based measures of mammographic density in women with and without cancer

Abstract

Conference

Keywords

UN SDGs

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