Water lubricates hydrogen-bonded molecular machines

Matthijs R. Panman, Bert H. Bakker, David Den Uyl, Euan R. Kay, David A. Leigh, Wybren Jan Buma, Albert M. Brouwer, Jan A J Geenevasen, Sander Woutersen

    Research output: Contribution to journalArticlepeer-review

    Abstract

    The mechanical behaviour of molecular machines differs greatly from that of their macroscopic counterparts. This applies particularly when considering concepts such as friction and lubrication, which are key to optimizing the operation of macroscopic machinery. Here, using time-resolved vibrational spectroscopy and NMR-lineshape analysis, we show that for molecular machinery consisting of hydrogen-bonded components the relative motion of the components is accelerated strongly by adding small amounts of water. The translation of a macrocycle along a thread and the rotation of a molecular wheel around an axle both accelerate significantly on the addition of water, whereas other protic liquids have much weaker or opposite effects. We tentatively assign the superior accelerating effect of water to its ability to form a three-dimensional hydrogen-bond network between the moving parts of the molecular machine. These results may indicate a more general phenomenon that helps explain the function of water as the 'lubricant of life'. © 2013 Macmillan Publishers Limited. All rights reserved.
    Original languageEnglish
    Pages (from-to)929-934
    Number of pages5
    JournalNature Chemistry
    Volume5
    Issue number11
    DOIs
    Publication statusPublished - Nov 2013

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