What accounts for the wide variation in life span of genetically identical organisms reared in a constant environment?

Thomas B L Kirkwood; Martin Feder; Caleb E. Finch; Claudio Franceschi; Amiela Globerson; Christian Peter Klingenberg; Kelly LaMarco; Stig Omholt; Rudi G J Westendorp

doi:10.1016/j.mad.2004.09.008

What accounts for the wide variation in life span of genetically identical organisms reared in a constant environment?

Thomas B L Kirkwood, Martin Feder, Caleb E. Finch, Claudio Franceschi, Amiela Globerson, Christian Peter Klingenberg, Kelly LaMarco, Stig Omholt, Rudi G J Westendorp

Research output: Contribution to journal › Article › peer-review

Abstract

Individual organisms show marked variability in life span, even when they are of the same genotype and are raised in a common environment protected from extrinsic hazards. This intrinsic variability of life span is thought to arise from the stochastic nature of the cellular and molecular mechanisms controlling development and ageing. In this article we review what is currently understood about the factors underlying the variability of life span and consider the implications for research that aims to improve the predictability of health in old age. © 2004 Elsevier Ireland Ltd. All rights reserved.

Original language	English
Pages (from-to)	439-443
Number of pages	4
Journal	Mechanisms of Ageing and Development
Volume	126
Issue number	3
DOIs	https://doi.org/10.1016/j.mad.2004.09.008
Publication status	Published - Mar 2005

Keywords

Ageing
Development
Environment
Errors
Genes
Longevity
Stochastic
Variation

Access to Document

10.1016/j.mad.2004.09.008

Cite this

@article{a350110602014fbda4a7dd64ea345301,

title = "What accounts for the wide variation in life span of genetically identical organisms reared in a constant environment?",

abstract = "Individual organisms show marked variability in life span, even when they are of the same genotype and are raised in a common environment protected from extrinsic hazards. This intrinsic variability of life span is thought to arise from the stochastic nature of the cellular and molecular mechanisms controlling development and ageing. In this article we review what is currently understood about the factors underlying the variability of life span and consider the implications for research that aims to improve the predictability of health in old age. {\textcopyright} 2004 Elsevier Ireland Ltd. All rights reserved.",

keywords = "Ageing, Development, Environment, Errors, Genes, Longevity, Stochastic, Variation",

author = "Kirkwood, {Thomas B L} and Martin Feder and Finch, {Caleb E.} and Claudio Franceschi and Amiela Globerson and Klingenberg, {Christian Peter} and Kelly LaMarco and Stig Omholt and Westendorp, {Rudi G J}",

year = "2005",

month = mar,

doi = "10.1016/j.mad.2004.09.008",

language = "English",

volume = "126",

pages = "439--443",

journal = "Mechanisms of Ageing and Development",

issn = "1872-6216",