Abstract
Objectives
Female physicians in medicine are increasing, but disparities in female authorship exist. The aim of this study was to characterise factors associated with female first (FF) and senior (SF) authorship in later phase systemic oncological clinical trials in biliary tract cancer (BTC) and identify any changes over time.
Setting
Embase/Medline identified trial publications in BTC (2000-2020) were included. Chi-square tests and log regression were used (assessed factors associated with FF and SF authorship, including changes over time (STATA16)).
Primary outcome measure
Female first (FF) and senior (SF) authorship in later phase systemic oncological clinical trials in biliary tract cancer.
Secondary outcome measure
Any changes over time?.
Results
Of 501 publications, 163 met inclusion criteria. The median percentage of female author representation in publications was 25%; there were no female authors in 13% of publications. Geographic location of the home institution of the first and senior authors were Asia (42%/42%), Europe (29%/29%), USA (24%/22%) and other (4%/6%), respectively. Overall, FF and SF author representation was 20% and 10%, respectively. The median position of the first female author was 2nd in all the publication author lists. The phase of trial, journal-impact factor, industry-funding, or whether the study met its primary endpoint did not impact FF/SF author representation. More SF authors had home institutions in “other” geographic locations (40% in 10 trials) (P=0.02) vs Asia (6%), Europe (8%) and USA (14%). There were no significant changes in FF/SF representation over time (P=0.61 and P=0.33 respectively).
Conclusions
Female first and senior author representation in later phase systemic clinical trial publications in BTC is low and has not changed significantly over time. The underlying reasons for this imbalance need to be better understood and addressed.
Female physicians in medicine are increasing, but disparities in female authorship exist. The aim of this study was to characterise factors associated with female first (FF) and senior (SF) authorship in later phase systemic oncological clinical trials in biliary tract cancer (BTC) and identify any changes over time.
Setting
Embase/Medline identified trial publications in BTC (2000-2020) were included. Chi-square tests and log regression were used (assessed factors associated with FF and SF authorship, including changes over time (STATA16)).
Primary outcome measure
Female first (FF) and senior (SF) authorship in later phase systemic oncological clinical trials in biliary tract cancer.
Secondary outcome measure
Any changes over time?.
Results
Of 501 publications, 163 met inclusion criteria. The median percentage of female author representation in publications was 25%; there were no female authors in 13% of publications. Geographic location of the home institution of the first and senior authors were Asia (42%/42%), Europe (29%/29%), USA (24%/22%) and other (4%/6%), respectively. Overall, FF and SF author representation was 20% and 10%, respectively. The median position of the first female author was 2nd in all the publication author lists. The phase of trial, journal-impact factor, industry-funding, or whether the study met its primary endpoint did not impact FF/SF author representation. More SF authors had home institutions in “other” geographic locations (40% in 10 trials) (P=0.02) vs Asia (6%), Europe (8%) and USA (14%). There were no significant changes in FF/SF representation over time (P=0.61 and P=0.33 respectively).
Conclusions
Female first and senior author representation in later phase systemic clinical trial publications in BTC is low and has not changed significantly over time. The underlying reasons for this imbalance need to be better understood and addressed.
| Original language | English |
|---|---|
| Journal | BMJ Open |
| Publication status | Accepted/In press - 22 Sept 2022 |
Research Beacons, Institutes and Platforms
- Manchester Cancer Research Centre
