White matter lesions account for all age-related declines in speed but not in intelligence

Patrick Rabbitt, Marietta Scott, Mary Lunn, Neil Thacker, Christine Lowe, Neil Pendleton, Mike Horan, Alan Jackson, Christine Rogers

    Research output: Contribution to journalArticlepeer-review


    MRI scans measured white matter lesion prevalence (WMLP) in 65 people ages 65-84 years who also took 17 cognitive tests: 3 tests of general fluid intelligence, 3 of vocabulary, 2 of episodic and 3 of working memory, 2 of processing speed, and 4 of frontal and executive function. Entry of age with WMLP into regression equations as predictors of test scores showed that inferences about the functional relationships between markers of brain aging and cognitive impairments are seriously misleading if they are based on simple correlations alone. A new finding that WMLP accounts for all of the age-related variance between individuals in tests of speed and executive ability but for none of the age-related variance in intelligence revises current hypotheses that gross brain changes affect general fluid intelligence and other mental abilities solely through their effects on information-processing speed. © 2007 APA, all rights reserved.
    Original languageEnglish
    Pages (from-to)363-370
    Number of pages7
    Issue number3
    Publication statusPublished - May 2007


    • Age
    • Intelligence
    • Speed
    • White matter lesions


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