White matter microstructural abnormalities in euthymic bipolar disorder

Karine A N Macritchie; Adrian J. Lloyd; Mark E. Bastin; Kamini Vasudev; Peter Gallagher; Rachel Eyre; Ian Marshall; Joanna M. Wardlaw; I. Nicol Ferrier; P. Brian Moore; Allan H. Young

doi:10.1192/bjp.bp.108.058586

White matter microstructural abnormalities in euthymic bipolar disorder

Karine A N Macritchie, Adrian J. Lloyd, Mark E. Bastin, Kamini Vasudev, Peter Gallagher, Rachel Eyre, Ian Marshall, Joanna M. Wardlaw, I. Nicol Ferrier, P. Brian Moore, Allan H. Young

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Abnormal diffusion parameters are reported in specific brain regions and white matter tracts in bipolar disorder. Aims: To investigate whether these abnormalities are generalised, and thus evident in large regions of white matter. Method: Diffusion parameters were measured at several regions in the corpus callosum and in deep/periventricular white matter in 28 currently euthymic patients with bipolar disorder and controls. White matter hyperintensity loads were assessed. Results: Comparing the whole data-sets using the sign test, in the group with bipolar disorder, mean diffusivity was greater at all 15 sites (P

Original language	English
Pages (from-to)	52-58
Number of pages	6
Journal	British Journal of Psychiatry
Volume	196
Issue number	1
DOIs	https://doi.org/10.1192/bjp.bp.108.058586
Publication status	Published - Jan 2010

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title = "White matter microstructural abnormalities in euthymic bipolar disorder",

abstract = "Background: Abnormal diffusion parameters are reported in specific brain regions and white matter tracts in bipolar disorder. Aims: To investigate whether these abnormalities are generalised, and thus evident in large regions of white matter. Method: Diffusion parameters were measured at several regions in the corpus callosum and in deep/periventricular white matter in 28 currently euthymic patients with bipolar disorder and controls. White matter hyperintensity loads were assessed. Results: Comparing the whole data-sets using the sign test, in the group with bipolar disorder, mean diffusivity was greater at all 15 sites (P",

author = "Macritchie, {Karine A N} and Lloyd, {Adrian J.} and Bastin, {Mark E.} and Kamini Vasudev and Peter Gallagher and Rachel Eyre and Ian Marshall and Wardlaw, {Joanna M.} and Ferrier, {I. Nicol} and Moore, {P. Brian} and Young, {Allan H.}",

note = ", Chief Scientist Office, United Kingdom",

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T1 - White matter microstructural abnormalities in euthymic bipolar disorder

AU - Macritchie, Karine A N

AU - Lloyd, Adrian J.

AU - Bastin, Mark E.

AU - Vasudev, Kamini

AU - Gallagher, Peter

AU - Eyre, Rachel

AU - Marshall, Ian

AU - Wardlaw, Joanna M.

AU - Ferrier, I. Nicol

AU - Moore, P. Brian

AU - Young, Allan H.

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PY - 2010/1

Y1 - 2010/1

N2 - Background: Abnormal diffusion parameters are reported in specific brain regions and white matter tracts in bipolar disorder. Aims: To investigate whether these abnormalities are generalised, and thus evident in large regions of white matter. Method: Diffusion parameters were measured at several regions in the corpus callosum and in deep/periventricular white matter in 28 currently euthymic patients with bipolar disorder and controls. White matter hyperintensity loads were assessed. Results: Comparing the whole data-sets using the sign test, in the group with bipolar disorder, mean diffusivity was greater at all 15 sites (P

AB - Background: Abnormal diffusion parameters are reported in specific brain regions and white matter tracts in bipolar disorder. Aims: To investigate whether these abnormalities are generalised, and thus evident in large regions of white matter. Method: Diffusion parameters were measured at several regions in the corpus callosum and in deep/periventricular white matter in 28 currently euthymic patients with bipolar disorder and controls. White matter hyperintensity loads were assessed. Results: Comparing the whole data-sets using the sign test, in the group with bipolar disorder, mean diffusivity was greater at all 15 sites (P

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DO - 10.1192/bjp.bp.108.058586

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SN - 0007-1250

VL - 196

SP - 52

EP - 58

JO - British Journal of Psychiatry

JF - British Journal of Psychiatry

IS - 1

ER -

White matter microstructural abnormalities in euthymic bipolar disorder

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