Wnt signalling in pituitary development and tumorigenesis

T. J G Chambers; A. Giles; G. Brabant; J. R E Davis

doi:10.1530/ERC-13-0005

Wnt signalling in pituitary development and tumorigenesis

T. J G Chambers, A. Giles, G. Brabant, J. R E Davis

Research output: Contribution to journal › Article › peer-review

Abstract

Wnt signalling is activated in both pituitary organogenesis and its mature function. Wnt ligands and Wnt signalling pathways are critical for the regulation of the formation of the pituitary. In the mature pituitary, Wnt signalling pathways control cell activity and may stimulate cell proliferation in both physiological and pathological processes. This review compares Wnt signalling pathways active in the developing and mature pituitary and explores how this gives us further insight into the development of pituitary adenomas. Copyright © 2013 Society for Endocrinology.

Original language	English
Pages (from-to)	R101-R111
Journal	Endocrine-related cancer
Volume	20
Issue number	3
DOIs	https://doi.org/10.1530/ERC-13-0005
Publication status	Published - Jun 2013

Keywords

Adenoma
Development
Pituitary
Tumorigenesis
Wnt

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http://erc.endocrinology-journals.org/content/20/3/R101.full.pdf+html

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title = "Wnt signalling in pituitary development and tumorigenesis",

abstract = "Wnt signalling is activated in both pituitary organogenesis and its mature function. Wnt ligands and Wnt signalling pathways are critical for the regulation of the formation of the pituitary. In the mature pituitary, Wnt signalling pathways control cell activity and may stimulate cell proliferation in both physiological and pathological processes. This review compares Wnt signalling pathways active in the developing and mature pituitary and explores how this gives us further insight into the development of pituitary adenomas. Copyright {\textcopyright} 2013 Society for Endocrinology.",

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AU - Brabant, G.

AU - Davis, J. R E

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AB - Wnt signalling is activated in both pituitary organogenesis and its mature function. Wnt ligands and Wnt signalling pathways are critical for the regulation of the formation of the pituitary. In the mature pituitary, Wnt signalling pathways control cell activity and may stimulate cell proliferation in both physiological and pathological processes. This review compares Wnt signalling pathways active in the developing and mature pituitary and explores how this gives us further insight into the development of pituitary adenomas. Copyright © 2013 Society for Endocrinology.

KW - Adenoma

KW - Development

KW - Pituitary

KW - Tumorigenesis

KW - Wnt

U2 - 10.1530/ERC-13-0005

DO - 10.1530/ERC-13-0005

M3 - Article

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VL - 20

SP - R101-R111

JO - Endocrine-related cancer

JF - Endocrine-related cancer

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ER -

Wnt signalling in pituitary development and tumorigenesis

Abstract

Keywords

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