Wnt signalling in pituitary development and tumorigenesis

T. J G Chambers, A. Giles, G. Brabant, J. R E Davis

    Research output: Contribution to journalArticlepeer-review


    Wnt signalling is activated in both pituitary organogenesis and its mature function. Wnt ligands and Wnt signalling pathways are critical for the regulation of the formation of the pituitary. In the mature pituitary, Wnt signalling pathways control cell activity and may stimulate cell proliferation in both physiological and pathological processes. This review compares Wnt signalling pathways active in the developing and mature pituitary and explores how this gives us further insight into the development of pituitary adenomas. Copyright © 2013 Society for Endocrinology.
    Original languageEnglish
    Pages (from-to)R101-R111
    JournalEndocrine-related cancer
    Issue number3
    Publication statusPublished - Jun 2013


    • Adenoma
    • Development
    • Pituitary
    • Tumorigenesis
    • Wnt


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