World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for Biological Treatment of Schizophrenia, part 1: update 2012 on the acute treatment of schizophrenia and the management of treatment resistance

Alkomiet Hasan, Peter Falkai, Thomas Wobrock, Birte Glenthoj, Wagner F Gattaz, Florence Thibaut, A Carlo Altamura (Collaborator), Nancy Andreasen (Collaborator), Thomas R E Barnes (Collaborator), M Emin Ceylan (Collaborator), Jorge Ciprian Ollivier (Collaborator), Timothy Crow (Collaborator), Aysen Esen Danaci (Collaborator), Anthony David (Collaborator), Michael Davidson (Collaborator), Bill Deakin (Collaborator), Helio Elkis (Collaborator), Lars Farde (Collaborator), Wolfgang Gaebel (Collaborator), Bernd Gallhofer (Collaborator)Jes Gerlach (Collaborator), Steven Richard Hirsch (Collaborator), Carlos Roberto Hojaij (Collaborator), Michael Hwang (Collaborator), Hai Gwo Hwo (Collaborator), Assen Verniaminov Jablensky (Collaborator), Marek Jarema (Collaborator), John Kane (Collaborator), Takuja Kojima (Collaborator), Veronica Larach (Collaborator), Jeffrey Lieberman (Collaborator), Patrick McGorry (Collaborator), Herbert Meltzer (Collaborator), Hans-Jürgen Möller (Collaborator), S Mosolov (Collaborator), Driss Moussaoui (Collaborator), Jean-Pierre Olié (Collaborator), Antonio Pacheco Palha (Collaborator), Asli Sarandöl (Collaborator), Mitsumoto Sato (Collaborator), Heinrich Sauer (Collaborator), Nina Schooler (Collaborator), Bilgen Taneli (Collaborator), Lars von Knorring (Collaborator), Daniel Weinberger (Collaborator), Shigeto Yamawaki (Collaborator)

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    Abstract

    These updated guidelines are based on a first edition of the World Federation of Societies of Biological Psychiatry Guidelines for Biological Treatment of Schizophrenia published in 2005. For this 2012 revision, all available publications pertaining to the biological treatment of schizophrenia were reviewed systematically to allow for an evidence-based update. These guidelines provide evidence-based practice recommendations that are clinically and scientifically meaningful and these guidelines are intended to be used by all physicians diagnosing and treating people suffering from schizophrenia. Based on the first version of these guidelines, a systematic review of the MEDLINE/PUBMED database and the Cochrane Library, in addition to data extraction from national treatment guidelines, has been performed for this update. The identified literature was evaluated with respect to the strength of evidence for its efficacy and then categorised into six levels of evidence (A-F; Bandelow et al. 2008b, World J Biol Psychiatry 9:242). This first part of the updated guidelines covers the general descriptions of antipsychotics and their side effects, the biological treatment of acute schizophrenia and the management of treatment-resistant schizophrenia.

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