Zebrafish for modelling stroke and their applicability for drug discovery and development

Siobhan Crilly, Emily Mcmahon, Paul Kasher

Research output: Contribution to journalReview articlepeer-review

Abstract

The global health burden of stroke is significant and few therapeutic treatment options currently exist for patients. Pre-clinical research relies heavily on rodent stroke models but the limitations associated with using these systems alone has meant translation of drug compounds to the clinic has not been greatly successful to date. Zebrafish disease modelling offers a potentially complementary platform for pre-clinical compound screening to aid the drug discovery process for translational stroke research
Original languageEnglish
JournalExpert Opinion on Drug Discovery
Publication statusAccepted/In press - 28 Apr 2022

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