Zinc mediated azide-alkyne ligation to 1,5- and 1,4,5-substituted 1,2,3-triazoles

Christopher D. Smith, Michael F. Greaney

    Research output: Contribution to journalArticlepeer-review

    Abstract

    A mild method for regioselective formation of 1,5-substituted 1,2,3-triazoles is described. The zinc-mediated reaction works at room temperature and is successful across a wide range of azido/alkynyl substrates. Additionally, the triazole 4-position can be further functionalized through the intermediate aryl-zinc to accommodate a diverse three-component coupling strategy. © 2013 American Chemical Society.
    Original languageEnglish
    Pages (from-to)4826-4829
    Number of pages3
    JournalOrganic Letters
    Volume15
    Issue number18
    DOIs
    Publication statusPublished - 20 Sept 2013

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