Assessment of Novel, Non-Invasive Interventions for the Prevention of Foot Ulceration in Patients with Diabetes and a Mechanistic Study of Progenitor Cells from Diabetic Patients

  • Ahmad Najib Bin Hasan

Student thesis: Phd

Abstract

Diabetic foot ulceration (DFU) is a known major complication of diabetes mellitus which contributes to lower extremities amputation. This study aimed to investigate the use of interventional devices either as a preventative or therapeutic strategy to improve clinical management of this pathology, as well as investigating the impaired function of endothelial progenitor cells in the diabetic condition. The first element targeted plantar callus formation among diabetic neuropathic (NRP) patients through the use of a SurroSenseRxTM biofeedback device. Reducing foot pressure with improved walking strategy in the 6 months study in diabetic neuropathy patients (n=20) appeared to minimise the size of non-ulcerative plantar callus (p
Date of Award1 Aug 2019
Original languageEnglish
Awarding Institution
  • The University of Manchester
SupervisorAndrew Boulton (Supervisor), Yvonne Alexander (Supervisor) & Frank Bowling (Supervisor)

Keywords

  • Diabetic Neuropathy
  • Diabetic Neuroischaemia
  • Diabetic Foot Ulceration
  • Plantar Pressure
  • Outgrowth Endothelial Cells
  • Electrical Stimulation

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