BIOFUNCTIONALISATION OF ALIGNED FIBRE SCAFFOLDS FOR ANTERIOR CRUCIATE LIGAMENT TISSUE ENGINEERING

  • Zara Smith

Student thesis: Phd

Abstract

Anterior cruciate ligament (ACL) tears and ruptures occur in approximately 150,000- 200,000 people every year in the USA, costing the health services approximately $7.6 billion USD. Gold standard repair techniques use the patellar tendon autograft, which has a 13% failure rate and associated pain and donor site morbidity. Synthetic grafts have been trialled, but can result in synovial infections and perpetual inflammation. Tissue engineering using biofunctionalised electrospun fibres is a novel method of regenerating ligament tissue by the harnessing physiologically relevant topographical cues, along with biologically relevant attachment sites, which guide cell morphology and reproduction of the native extracellular matrix. Electrospun microfibre scaffolds displayed alignment for across all batches, though showed variable physical (e.g. porosity p
Date of Award1 Aug 2022
Original languageEnglish
Awarding Institution
  • The University of Manchester
SupervisorJulie Gough (Supervisor) & Yi Li (Supervisor)

Keywords

  • fibrillin-1
  • tissue engineering
  • extracellular matrix
  • anterior cruciate ligament
  • biomaterials

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