Characterisation of a Susceptibility Locus for Inflammatory Arthritis

  • Kathryn Steel

    Student thesis: Phd


    Inflammatory arthritis (IA) types such as rheumatoid arthritis (RA), juvenile idiopathic arthritis (JIA) and psoriatic arthritis (PsA) have been shown to exhibit common clinical features. As complex diseases they have a known genetic component, some of which is known to be shared. The aim of this study was to assess the genetic overlap between 3 types of IA (RA, JIA and PsA) using genotype data generated on the Immunochip array and to select a biologically promising overlapping region for further genetic and functional investigation.Overlap analysis was performed using association data generated for a large cohort of inflammatory arthritis cases and shared controls (11,475 RA; 2816 JIA; 929 PsA respectively). 50 genetic regions were identified as being associated with more than 1 type of IA (p
    Date of Award1 Aug 2015
    Original languageEnglish
    Awarding Institution
    • The University of Manchester
    SupervisorWendy Thomson (Supervisor), Anne Hinks (Supervisor) & Anne Barton (Supervisor)


    • psoriatic arthritis
    • juvenile idiopathic arthritis
    • rheumatoid arthritis
    • genomics
    • rheumatology

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