Childhood adversity in bipolar disorder and psychosis

Abstract

The relationship between childhood adversity and bipolar disorder remains unclear. The authors statistically synthesised the available literature in order to understand the size of this effect. In line with the review protocol (PROSPERO reference: CRD42015017201), search terms relating to childhood adversity and bipolar disorder were entered into four electronic databases (Medline, Embase, PsychInfo, and Web of Science). Eligible studies included a sample formally diagnosed with bipolar disorder, a comparison sample (non-clinical, major depression or schizophrenia) and a quantitative measure of childhood adversity. Effect sizes were calculated and converted to odds ratios before being meta-analysed. From the 5395 identified articles, 13 case-control and six epidemiological studies were included in the main analysis. Childhood adversity was 2.63 (CI: 1.99 - 3.47, p

Date of Award	31 Dec 2015
Original language	English
Awarding Institution	The University of Manchester
Supervisor	Sandra Bucci (Supervisor) & Katherine Berry (Supervisor)