CURATING AND ANALYSING THE GENOME OF A MODEL EUKARYOTE

Abstract

This work describes the biocuration of the fission yeast Schizosaccharomyces pombe, and how this has contributed to the development of fission yeast as a model species. I recount the curation and refinement of the gene complement, and manually curated ortholog inventories and describe how these two resources have been pivotal for comparative analysis. I outline the mechanisms of functional curation using ontologies, the PomBase community curation initiative and ongoing curation work to construct a qualitative model of cellular pathways. I describe how functional curation has been used to analyse important genome-wide datasets. Finally, the tools and resources developed to curate, display and enable interrogation and reuse of data are outlined.

Date of Award	31 Dec 2019
Original language	English
Awarding Institution	The University of Manchester