Developing Tools for SimulatingBiological Flows

Abstract

The long term aim of this work is to investigate and develop efficient methods to analyse systems involving biological flows with fluid structure interaction, particularly cerebral aneurysms. Cerebral aneurysms are extremely complex biological structures and this work develops some of the groundwork required to eventually build the capability to efficiently simulate them computationally. This will enable the prediction of a patient specific risk model to aid in surgical decisions on a day to day basis or in large scale studies.Fibrous immersed dynamic structures of cerebral aneurysms seem suited to immersed boundary method simulations. Because of this numerous Immersed Boundary methods are investigated to determine if they present a viable approach, and which of these is best suited.A number of different computational tools have been built and investigated using FFTW, Eigen, OpenMP, and GNU OCTAVE to meet the requirements to allow numerous implicit and explicit approaches to be investigated. These tools are validated and tested for a number of cases. Preliminary work is also presented aimed at generating physically representative numerical models from MRI scans.

Date of Award	31 Dec 2014
Original language	English
Awarding Institution	The University of Manchester