A connective Pummerer-type cyclisation has been developed for an approach to the synthesis of ecteinascidin 597.Several electron rich glyoxamide substrates have been prepared and conditions for the connective Pummerer-type cyclisation have been developed successfully. In addition, the connective Pummerer-type cyclisation has been used with simple aldehyde substrates for the first time.The tetrahydroisoquinoline AB system of ecteinascidin 597 has been prepared successfully using the connective Pummerer-type cyclisation. The H ring has also been built. Several approaches for the synthesis of ecteinascidin 597 from the AB and ABH ring systems have been investigated.
|Date of Award||31 Dec 2013|
- The University of Manchester
|Supervisor||David Procter (Supervisor)|