Development of a Pummerer-type cyclisation for an approach to ecteinascidin 597

  • Trung Nguyen

Student thesis: Phd


A connective Pummerer-type cyclisation has been developed for an approach to the synthesis of ecteinascidin 597.Several electron rich glyoxamide substrates have been prepared and conditions for the connective Pummerer-type cyclisation have been developed successfully. In addition, the connective Pummerer-type cyclisation has been used with simple aldehyde substrates for the first time.The tetrahydroisoquinoline AB system of ecteinascidin 597 has been prepared successfully using the connective Pummerer-type cyclisation. The H ring has also been built. Several approaches for the synthesis of ecteinascidin 597 from the AB and ABH ring systems have been investigated.
Date of Award31 Dec 2013
Original languageEnglish
Awarding Institution
  • The University of Manchester
SupervisorDavid Procter (Supervisor)

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