A connective Pummerer-type cyclisation has been developed for an approach to the synthesis of ecteinascidin 597.Several electron rich glyoxamide substrates have been prepared and conditions for the connective Pummerer-type cyclisation have been developed successfully. In addition, the connective Pummerer-type cyclisation has been used with simple aldehyde substrates for the first time.The tetrahydroisoquinoline AB system of ecteinascidin 597 has been prepared successfully using the connective Pummerer-type cyclisation. The H ring has also been built. Several approaches for the synthesis of ecteinascidin 597 from the AB and ABH ring systems have been investigated.
| Date of Award | 31 Dec 2013 |
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| Original language | English |
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| Awarding Institution | - The University of Manchester
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| Supervisor | David Procter (Supervisor) |
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Development of a Pummerer-type cyclisation for an approach to ecteinascidin 597
Nguyen, T. (Author). 31 Dec 2013
Student thesis: Phd