Development of an approach to novel hybrid analogues of COTC and Antheminone A as potential anticancer agents

Abstract

The glyoxalase pathway is vital for the survival of many organisms and is an important focus of research in the area of cancer. A number of antiproliferative agents have been isolated from natural sources, including COTC, antheminone A, the phorbasins and the gabosines, which share a common alpha-oxyalkylcyclohex-2-enone moiety. These compounds are believed to interfere with the glyoxalase pathway, however their precise mechanism of action still remains unknown. As a continuation of previous research this study was concerned with the synthesis of novel hybrid analogues of COTC and antheminone A, which were selected in order to gain important information regarding the ideal C5 substituent for optimum bioactivity. Compounds which contained a bromophenyl substituent were therefore synthesised which subsequently will be assayed for their antiproliferative activity towards non-small-cell lung cancer cell lines.

Date of Award	1 Aug 2014
Original language	English
Awarding Institution	The University of Manchester
Supervisor	Roger Whitehead (Supervisor) & David Procter (Supervisor)