Epstein-Barr Virus Infection in Adult Renal Transplant Recipients

  • David Morton

    Student thesis: Phd

    Abstract

    Aims: To explore the clinical significance of EBV infection in adult renal transplant recipients when detected in the late post-transplant period.Methods: (1) A prospective observational study recruiting 499 stable adult kidney transplant recipients with serial blood sampling for EBV DNAemia and assessment of clinical outcomes and associated factors. (2) A retrospective analysis of PTLD incidence, timing and outcomes in relation to EBV infection. Results: EBV DNAemia in stable kidney transplant recipients is common, found in 46% of recruited individuals screened over 1 year, with persistent DNAemia seen in 10%. DNAemia prevalence increased significantly with time from transplant (p
    Date of Award9 Oct 2013
    Original languageEnglish
    Awarding Institution
    • The University of Manchester
    SupervisorPamela Vallely (Main Supervisor), Paul Klapper (Co Supervisor) & Michael Picton (Co Supervisor)

    Keywords

    • Immunosuppression
    • Kidney
    • Post-transplant lymphoproliferative disorder
    • Epstein-Barr virus
    • Transplant

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