Investigating the Molecular Mechanisms Underlying Lipo-toxicity in Diabetic Cardiomyopathy: KLB and FGFR1 Interaction and Signaling

  • Jiahan Shen

Student thesis: Master of Philosophy


Diabetic cardiomyopathy (DCM) is described as cardiac dysfunction that occurs in the absence of coronary artery disease, hypertension, or valvular heart disease in people with diabetes. Current studies have shown that cellular mechanisms and metabolic disorders are involved in the formation of diabetic cardiomyopathy. Beta Klotho (KLB) and fibroblast growth receptor 1 (FGFR1) intracellular signaling and pathways have been found to be important in the brain, liver and kidney, but its role and function in cardiomyocyte remains unknown. Therefore, the objective of this study is to investigate whether KLB- FGFR1 signaling mediates the beneficial effects under cardiac lipid metabolism.
Date of Award31 Dec 2023
Original languageEnglish
Awarding Institution
  • The University of Manchester
SupervisorElizabeth Cartwright (Supervisor), Alan Whitmarsh (Supervisor) & Wei Liu (Supervisor)


  • KLB
  • FGFR1

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