Metal-Free Sulfoxide-Directed Cross-Coupling

  • Kevin Yang

Student thesis: Master of Philosophy


Metal-catalysed cross-coupling reactions enable the selective formation of carbon-carbon bonds, which is crucial in the synthesis of pharmaceuticals and materials. Most of these cross-coupling reactions are catalysed by late transition metals, such as palladium, which are expensive and/or toxic. The development of alternative cross-coupling procedures that do not rely on the use of metals would therefore be attractive. In this work, the metal-free sulfoxide-directed cross-coupling method has been further developed to provide a viable alternative to transition metal- catalysed cross-coupling. The metal-free process has been applied to the construction of C3-arylated benzo[b]furans.
Date of Award1 Aug 2019
Original languageEnglish
Awarding Institution
  • The University of Manchester
SupervisorDavid Procter (Supervisor) & Alexander Pulis (Supervisor)

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