Metal-catalysed cross-coupling reactions enable the selective formation of carbon-carbon bonds, which is crucial in the synthesis of pharmaceuticals and materials. Most of these cross-coupling reactions are catalysed by late transition metals, such as palladium, which are expensive and/or toxic. The development of alternative cross-coupling procedures that do not rely on the use of metals would therefore be attractive. In this work, the metal-free sulfoxide-directed cross-coupling method has been further developed to provide a viable alternative to transition metal- catalysed cross-coupling. The metal-free process has been applied to the construction of C3-arylated benzo[b]furans.
|Date of Award||1 Aug 2019|
- The University of Manchester
|Supervisor||David Procter (Supervisor) & Alexander Pulis (Supervisor)|