Molecular Machines for Transport, Catalysis and Pumping

Abstract

Molecular machines are used in nature to carry out a wide range of sophisticated functions. These biological machines are remarkable in their efficiency and specificity but with this comes a great deal of complexity. As a result, precise analysis of their mode of operation becomes difficult to decipher. As synthetic chemists, we are able to design and construct molecules using a vast toolbox of chemical transformations. This thesis demonstrates the range of functions artificial molecular machines can be designed to perform. Firstly, a molecular transporter than can selectively move a cargo between four sites by judicious control of stimuli. Secondly, a mechanically chiral catenane-based structure that performs allosterically controlled asymmetric catalysis. Finally, a daisy chain polymer based on a molecular pump system that translates molecular motion across length scales to alter its macroscopic physical properties with sequential additions of acid and base.

Date of Award	1 Aug 2022
Original language	English
Awarding Institution	The University of Manchester
Supervisor	David Leigh (Supervisor) & Michael Greaney (Supervisor)