a-Amido sulfonium salts are bench-stable, readily prepared, user-friendly precursors of a-amidyl radicals. These salts are largely explored, engaging in metal-free photocatalytic cross-coupling protocols. This approach has been successfully applied to the synthesis of a-alkylated and a-alkenylated amides, via the formation of challenging C(sp3)âC(sp3) bonds and C(sp3)âC(sp2) bonds. The desired products were obtained in generally moderate to good yield and the processes tolerate a great variety of structural features and functional groups on both coupling partners. The sulfonium salts undergo reduction and trapping of the resultant radicals by different radical traps, enabling the chemodivergent a-alkylation and a-alkenylation of amides.
| Date of Award | 1 Aug 2025 |
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| Original language | English |
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| Awarding Institution | - The University of Manchester
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| Supervisor | James Rossi-Ashton (Supervisor) & David Procter (Supervisor) |
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Photoactivation of sulfonium salts for sustainable metalâfree crossâcoupling
Tian, W. (Author). 1 Aug 2025
Student thesis: Master of Philosophy