Studies on Mechanically Interlocked Molecules: From Wasserman`s Catenane to Molecular Pumps

Abstract

Artificial molecular machines capable of mechanical movement and synthetic tasks are now being routinely reported. Their development has progressed hand in hand with the discovery of newer, more reliable routes to synthesise interlocked architectures, such as rotaxanes and catenanes. These mechanically bonded structures are extremely good candidates for implementation into artificial molecular machines due to their components being able to perform ample rotational and/or translational movements, while remaining associated with each other. Herein, we present the synthesis of interlocked architectures using both archaic (Chapter 2) and novel strategies (Chapters 3, 4 and 5). At the same time, we showcase how interlocked architectures can be incorporated into molecular machines capable of performing sequence-specific synthesis (Chapter 3) and directional cargo transport (Chapter 4).

Date of Award	31 Dec 2023
Original language	English
Awarding Institution	The University of Manchester
Supervisor	David August (Supervisor) & David Leigh (Supervisor)