STUDY OF ENDOTHELIAL DYSFUNCTION IN PATIENTS WITH TYPE 2 DIABETES MELLITUS

Abstract

The rising epidemic of diabetes mellitus is likely to result in increased morbidity and mortality in the future. The chronic hyperglycaemia leading to diabetic microvascular and macrovascular sequelae affects multiple organs and an understanding of the mechanisms involved will help find solutions for many diabetic complications. Endothelial dysfunction is an independent predictor of cardiovascular disease, particularly in patients with type 2 diabetes. Testosterone deficiency is being increasingly recognized as an association of type 2 diabetes mellitus, in particular. Several studies have investigated the effects of testosterone replacement on metabolic dysfunction in hypogonadic men with type 2 diabetes, but there have been no studies specifically looking at endothelial dysfunction and the microcirculation in patients with diabetes and hypogonadism. This preliminary study aimed to investigate the effects of TRT (intramuscular testosterone undecanoate-Nebido, 1gm/ 4ml every 3 months for 12 months) on endothelial dysfunction in 24 men, aged 40 to 80 years, mean age 61.2 ± 8 years, with type 2 diabetes and hypogonadism. At week 30, significant improvements were noted from baseline following TRT, namely in endothelial vasodilatation, which was significant for SNP-mediated vasodilation [baseline: 47.14 ± 25.7 % vs week 30: 75.8 ± 40%, p

Date of Award	31 Dec 2017
Original language	English
Awarding Institution	The University of Manchester
Supervisor	Edward Jude (Supervisor) & Deepak Bhatnagar (Supervisor)